Article

Brain region-specific changes in neurons and glia and dysregulation of dopamine signaling in <i>Grin2a</i> mutant mice

2022-11-15

Abstract excerpt

<h4>SUMMARY</h4> Schizophrenia disease mechanisms remain poorly understood, in large part due to a lack of valid animal models. Rare heterozygous loss-of-function mutations in GRIN2A , encoding a subunit of the NMDA (N-methyl-d-aspartate) receptor, greatly increase the risk of schizophrenia. By transcriptomic, proteomic, electroencephalogram (EEG) recording and behavioral analysis, we report that heterozygous G...

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Literature Corpus work: 6348f595-c58a-573a-8bcd-91954b992ff8
DOI: 10.1101/2022.11.15.516665

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