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Article

Combination of Haloperidol With UNC9994, β-arrestin-Biased Analog of Aripiprazole, Ameliorates Schizophrenia-Related Phenotypes Induced by NMDAR Deficit in Mice.

The international journal of neuropsychopharmacology - 1 Dec 2024

Lipina Tatiana V, Giang Huy, Thacker Jonathan S, Wetsel William C, Caron Marc G, Beaulieu Jean Martin, Salahpour Ali, Ramsey Amy J

Abstract excerpt

BACKGROUND: Glutamatergic system dysfunction contributes to a full spectrum of schizophrenia-like symptoms, including the cognitive and negative symptoms that are resistant to treatment with antipsychotic drugs (APDs). Aripiprazole, an atypical APD, acts as a dopamine partial agonist, and its combination with haloperidol (a typical APD) has been suggested as a potential strategy to improve schizophrenia....

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Identifiers

PMID: 39612588
DOI: 10.1093/ijnp/pyae060
PMCID: PMC11656026

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