Article

KarXT Combines the Partial Benefits of Haloperidol for Positive Symptoms and Sulpiride for Negative Symptoms: Evidence from Computational Biology

2024-12-23

Abstract excerpt

<title>Abstract</title> <p>The new drug KarXT is a combination of xanomeline and trospium. KarXT is a unique antipsychotic that targets muscarinic receptors to reduce the positive and negative symptoms of schizophrenia. Haloperidol affects the positive symptoms and sulpiride affects the negative symptoms of schizophrenia. The shared and distinct molecular mechanisms of these three drugs are unclear. The objective...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8fa614b5-a99e-513d-ab16-f1c2d3d94e49
DOI: 10.21203/rs.3.rs-5562376/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

KarXT Combines the Partial Benefits of Haloperidol for Positive Symptoms and Sulpiride for Negative Symptoms: Evidence from Computational BiologyDOI 10.21203/rs.3.rs-5562376/v1Read

The Clinical Antipsychotic Effect of Recently Developed Antipsychotic Drugs in SchizophreniaSemantic proximity Read

Uncovering novel therapeutics for schizophrenia: a multitarget approach using the CANDO platformSemantic proximity Read

Pharmacologic and genetic evidence converge on mechanisms of psychotic illnessSemantic proximity Read

A Meta-Analysis of the Converging Effects of Different Classes of Antipsychotics on the Frontal Cortex Transcriptome in Laboratory Rodents and Non-Human PrimatesSemantic proximity Read

Discovery and Identification of Candidate Genes, Diagnostic Model and Drug Predictions for Schizophrenia and Crohn's Disease Through Integrated Bioinformatics Analysis and Machine LearningSemantic proximity Read

The role of antipsychotics and other drugs on the development and progression of Neuroleptic Malignant SyndromeSemantic proximity Read

Schizophrenia: from mechanism to therapy.Semantic proximity Read

Potentially repurposable drugs for schizophrenia identified from its interactomeSemantic proximity Read

Candidates for Drug Repurposing to Address the Cognitive Symptoms in SchizophreniaSemantic proximity Read

Desloratadine Rescues Schizophrenia-like Phenotypes by Inhibiting the Pathogenic 5-HT2AR-PI3K/AKT/mTOR Signaling Axis.Semantic proximity Read

An Effective Method to Facilitate Personalized and Precise Medicine for Schizophrenia Treatment Based on PharmacogenomicsSemantic proximity Read

Drugs that act on both GPCRs and kinases: Potentiation of effects, side effects and general aspects of drug pleiotropySemantic proximity Read