Article

The antipsychotic medications aripiprazole, brexpiprazole and cariprazine are off-target respiratory chain complex I inhibitors

2023-04-03

Abstract excerpt

<h4>Summary</h4> Antipsychotic drugs are the mainstay of treatment for schizophrenia and provide adjunct therapies for other prevalent psychiatric conditions, including bipolar disorder and major depressive disorder. However, they also induce debilitating extrapyramidal syndromes (EPS), such as Parkinsonism, in a significant minority of patients. The majority of antipsychotic drugs function as dopamine receptor a...

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Literature Corpus work: 40894c01-8bd7-547c-8005-dfab9c2d74b1
DOI: 10.1101/2023.04.02.535223

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