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Article

NR1 knockdown mice as a representative model of the glutamate hypothesis of schizophrenia.

Progress in brain research - 1 Jan 2009

Ramsey Amy J

Abstract excerpt

N-methyl d-aspartate (NMDA) receptor subunit NR1 knockdown (NR1-KD) mice have a global reduction of NMDA receptors, enabling their use as a genetic model to study the role of NMDA receptors in the pathophysiology of schizophrenia. This targeted mutation results in a spectrum of altered behaviors that are similar to those induced by NMDA receptor antagonists, which have long been used to model schizophrenia in...

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PMID: 20302817
DOI: 10.1016/S0079-6123(09)17906-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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