Article

Gαq Mediates Clozapine Effects in <i>Caenorhabditis</i> elegans

2017-01-24

Abstract excerpt

<h4>ABSTRACT</h4> Clozapine binds and has significant effects on multiple neurotransmitter receptors, notably including some dopamine receptors. Downstream of these receptors, clozapine affects the balance of Gi− and Gq-dependent second-messenger signaling. We used Caenorhabiditis elegans as a genetic model to study further how clozapine affects both dopamine receptors and downstream Gq mediated signaling. Four...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6f6e8c59-f8ea-5556-9d82-e3938a523fa7
DOI: 10.1101/101998

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Gαq Mediates Clozapine Effects in <i>Caenorhabditis</i> elegansDOI 10.1101/101998Read

A Genome-Wide RNAi Screen in Caenorhabditis elegans Identifies the Nicotinic Acetylcholine Receptor Subunit ACR-7 as an Antipsychotic Drug TargetSemantic proximity Read

A small-molecule screen in C. elegans yields a new calcium channel antagonist.Semantic proximity Read

Caenorhabditis elegans provides an efficient drug screening platform for GNAO1-related disorders and highlights the potential role of caffeine in controlling dyskinesia.Semantic proximity Read

Genetic pharmacology: interactions between drugs and gene products in Caenorhabditis elegans.Semantic proximity Read

Transient receptor potential melastatin (TRPM) channels mediate clozapine-induced phenotypes in Caenorhabditis elegans.Semantic proximity Read

Phenotypic Assessment of Pathogenic Variants in GNAO1 and Response to Caffeine in C. elegans Models of the Disease.Semantic proximity Read

A <i>C. elegans</i> genome-wide RNAi screen for altered levamisole sensitivity identifies genes required for muscle functionSemantic proximity Read

Haloperidol Interactions with the dop-3 Receptor in Caenorhabditis elegans.Semantic proximity Read

Functional analysis of epilepsy-associated GABAA receptor mutations using Caenorhabditis elegans.Semantic proximity Read

Novel pharmacological modulation of dystonic phenotypes caused by a gain-of-function mutation in the Na+ leak-current channel.Semantic proximity Read

STR-33, a novel G protein-coupled receptor that regulates locomotion and egg laying in Caenorhabditis elegans.Semantic proximity Read

The relevance of Caenorhabditis elegans genetics for understanding human psychiatric disease.Semantic proximity Read