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Article

Discovering non-additive heritability using additive GWAS summary statistics.

eLife - 24 Jun 2024

Pattillo Smith Samuel, Darnell Gregory, Udwin Dana, Stamp Julian, Harpak Arbel, Ramachandran Sohini, Crawford Lorin

Abstract excerpt

LD score regression (LDSC) is a method to estimate narrow-sense heritability from genome-wide association study (GWAS) summary statistics alone, making it a fast and popular approach. In this work, we present interaction-LD score (i-LDSC) regression: an extension of the original LDSC framework that accounts for interactions between genetic variants. By studying a wide range of generative models in simulations,...

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Identifiers

PMID: 38913556
DOI: 10.7554/eLife.90459
PMCID: PMC11196113

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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