Article
Finding the missing heritability of complex diseases.
Nature - 8 Oct 2009
Manolio Teri A, Collins Francis S, Cox Nancy J, Goldstein David B, Hindorff Lucia A, Hunter David J, McCarthy Mark I, Ramos Erin M, Cardon Lon R, Chakravarti Aravinda, Cho Judy H, Guttmacher Alan E, Kong Augustine, Kruglyak Leonid, Mardis Elaine, Rotimi Charles N, Slatkin Montgomery, Valle David, Whittemore Alice S, Boehnke Michael, Clark Andrew G, Eichler Evan E, Gibson Greg, Haines Jonathan L, Mackay Trudy F C, McCarroll Steven A, Visscher Peter M
Abstract excerpt
Genome-wide association studies have identified hundreds of genetic variants associated with complex human diseases and traits, and have provided valuable insights into their genetic architecture. Most variants identified so far confer relatively small increments in risk, and explain only a small proportion of familial clustering, leading many to question how the remaining, 'missing' heritability can be...
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