Article
Two-Stage Testing for Epistasis: Screening and Verification.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2021
Pecanka Jakub, Jonker Marianne A
Abstract excerpt
Undiscovered gene-to-gene interaction (epistasis) is a possible explanation for the "missing heritability" of complex traits and diseases. On a genome-wide scale, screening for epistatic effects among all possible pairs of genetic markers faces two main complications. Firstly, the classical statistical methods for modeling epistasis are computationally very expensive, which makes them impractical on such large...
Topics
Join the communities discussing this publication.