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Article

Two-Stage Testing for Epistasis: Screening and Verification.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2021

Pecanka Jakub, Jonker Marianne A

Abstract excerpt

Undiscovered gene-to-gene interaction (epistasis) is a possible explanation for the "missing heritability" of complex traits and diseases. On a genome-wide scale, screening for epistatic effects among all possible pairs of genetic markers faces two main complications. Firstly, the classical statistical methods for modeling epistasis are computationally very expensive, which makes them impractical on such large...

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Identifiers

PMID: 33733351
DOI: 10.1007/978-1-0716-0947-7_6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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