Detecting epistasis in human complex traits.

Abstract excerpt

Genome-wide association studies (GWASs) have become the focus of the statistical analysis of complex traits in humans, successfully shedding light on several aspects of genetic architecture and biological aetiology. Single-nucleotide polymorphisms (SNPs) are usually modelled as having additive, cumulative and independent effects on the phenotype. Although evidently a useful approach, it is often argued that this...

Topics

• Algorithms
• Epistasis, Genetic
• Genome, Human
• Genome-Wide Association Study
• Genotype
• Humans
• Linkage Disequilibrium
• Models, Biological
• Phenotype
• Polymorphism, Single Nucleotide