A perspective on epistasis: limits of models displaying no main effect.

doi:10.1086/338759

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Article

A perspective on epistasis: limits of models displaying no main effect.

American journal of human genetics - 1 Feb 2002

Culverhouse Robert, Suarez Brian K, Lin Jennifer, Reich Theodore

Abstract excerpt

The completion of a draft sequence of the human genome and the promise of rapid single-nucleotide-polymorphism-genotyping technologies have resulted in a call for the abandonment of linkage studies in favor of genome scans for association. However, there exists a large class of genetic models for which this approach will fail: purely epistatic models with no additive or dominance variation at any of the...

Topics

Alleles
Case-Control Studies
Chromosome Mapping
Epistasis, Genetic
Genetic Predisposition to Disease
Genotype
Humans
Linkage Disequilibrium
Models, Genetic
Nuclear Family
Penetrance

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Identifiers

PMID: 11791213
DOI: 10.1086/338759
PMCID: PMC384920

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