Article

A lifespan transcriptomic atlas of the human prefrontal cortex at single-cell resolution

2024-11-07

Abstract excerpt

The dorsolateral prefrontal cortex (DLPFC) underpins higher cognitive functions and is highly susceptible to age-related decline. However, a comprehensive, lifespan-resolved map of its cellular and molecular programs has been lacking. Here, we constructed the first single-nucleus transcriptomic atlas of the human DLPFC, spanning the full lifespan, profiling over 1.3 million nuclei from 284 postmortem samples rangi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6dfdbedc-4b74-5d44-89f8-3a95ed279d36
DOI: 10.1101/2024.11.06.24316592

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A lifespan transcriptomic atlas of the human prefrontal cortex at single-cell resolutionDOI 10.1101/2024.11.06.24316592Read

Aging-related Transcriptomic Changes with Spatial Resolution in the Human Prefrontal CortexSemantic proximity Read

A single-cell transcriptome atlas of cell diversity in human prefrontal cortex across the postnatal lifespanSemantic proximity Read

A Population-scale Single-cell Spatial Transcriptomic Atlas of the Human CortexSemantic proximity Read

Uncovering the Signatures of Cellular Senescence in the Human Dorsolateral Prefrontal CortexSemantic proximity Read

Human brain cell-type-specific aging clocks based on single-nuclei transcriptomicsSemantic proximity Read

Spatial Dissection of the Distinct Cellular Responses to Normal Aging and Alzheimer’s Disease in Human Prefrontal Cortex at Single-Nucleus ResolutionSemantic proximity Read

Single-cell, multi-region profiling of the macaque brain across the lifespanSemantic proximity Read

HypoAD: volumetric and single-cell analysis reveals changes in the human hypothalamus in aging and Alzheimer’s diseaseSemantic proximity Read

An Epigenetic Signature of Vulnerable Neurons is Under Selective Pressure Associated with Longevity Across Placental Mammals.Semantic proximity Read

Single-cell atlas of transcriptomic vulnerability across multiple neurodegenerative and neuropsychiatric diseasesSemantic proximity Read

Region-Specific Transcriptional Signatures of Brain Aging in the Absence of Neuropathology at the Single-cell LevelSemantic proximity Read

Epigenetic and 3D genome reprogramming during the aging of human hippocampusSemantic proximity Read