Article

Human brain cell-type-specific aging clocks based on single-nuclei transcriptomics

2025-03-02

Abstract excerpt

<h4>ABSTRACT</h4> Aging is the primary risk factor for most neurodegenerative diseases, yet the cell-type-specific progression of brain aging remains poorly understood. Here, we developed human cell-type-specific transcriptomic aging clocks using high-quality single-nucleus RNA sequencing data from post mortem human prefrontal cortex tissue of 31 donors aged 18 – 94 years, encompassing 73,941 high-quality nuclei....

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Literature Corpus work: 95642a12-f27d-58c6-8ab7-2ab3e778c788
DOI: 10.1101/2025.02.28.640749

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