Article

Region-Specific Transcriptional Signatures of Brain Aging in the Absence of Neuropathology at the Single-cell Level

2023-08-01

Abstract excerpt

Given that age is a significant risk factor for multiple neurodegenerative diseases, investigating normal brain aging may help identify molecular events that may contribute to increased disease risk over time. Single-nucleus RNA sequencing (snRNA-seq) enables analysis of gene expression changes within specific cell-types, potentially offering insights into the molecular mechanisms underlying aging. However, most b...

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Literature Corpus work: abb09e28-2128-57df-b7fa-3478d9d10df0
DOI: 10.1101/2023.07.31.551097

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