Article

Spatial Dissection of the Distinct Cellular Responses to Normal Aging and Alzheimer’s Disease in Human Prefrontal Cortex at Single-Nucleus Resolution

2024-05-22

Abstract excerpt

<h4>ABSTRACT</h4> Aging significantly elevates the risk for Alzheimer’s disease (AD), contributing to the accumulation of AD pathologies, such as amyloid-β (Aβ), inflammation, and oxidative stress. The human prefrontal cortex (PFC) is highly vulnerable to the impacts of both aging and AD. Unveiling and understanding the molecular alterations in PFC associated with normal aging (NA) and AD is essential for elucidat...

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Literature Corpus work: f113fa73-3309-57f8-b81c-55cea079bc45
DOI: 10.1101/2024.05.21.24306783

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