Article

Epigenetic and 3D genome reprogramming during the aging of human hippocampus

2024-10-17

Abstract excerpt

Age-related cognitive decline is associated with altered physiology of the hippocampus. While changes in gene expression have been observed in aging brain, the regulatory mechanisms underlying these changes remain underexplored. We generated single-nucleus gene expression, chromatin accessibility, DNA methylation, and 3D genome data from 40 human hippocampal tissues spanning adult lifespan. We observed a striking...

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Literature Corpus work: 0aca0235-9773-59d9-b40d-9a1067e9675d
DOI: 10.1101/2024.10.14.618338

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