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Article

Aging-related Transcriptomic Changes with Spatial Resolution in the Human Prefrontal Cortex

2026-01-12

Abstract excerpt

The human prefrontal cortex (PFC), whose laminar organization is essential for cognitive function, is among the first regions to show age-related functional decline 1,2 . Single-cell sequencing studies revealed cell type–dependent aging effects but lacked spatial specificity 3–6 . Spatial transcriptomics (ST) advanced our molecular understanding of the human PFC 7 , yet whether aging-driven changes differ acros...

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Literature Corpus work
960d7ed3-56d6-599a-ab06-d3d802dc4cac
DOI
10.64898/2026.01.12.698703
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Aging-related Transcriptomic Changes with Spatial Resolution in the Human Prefrontal CortexDOI 10.64898/2026.01.12.698703
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