Article

A Population-scale Single-cell Spatial Transcriptomic Atlas of the Human Cortex

2025-10-14

Abstract excerpt

<h4>Summary</h4> The genetic and spatial determinants of cell type diversity in human cerebral cortices remain poorly defined. Here, we present a population-level single-cell spatial transcriptomic atlas of human cortices from 71 donors across the lifespan. We identified 906 layer-specific genes showing conserved and divergent laminar expression patterns between humans and other species. Spatial analysis revealed...

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Identifiers and source

Literature Corpus work: 097fb901-5fa2-54db-9acb-4fe150b06059
DOI: 10.1101/2025.10.13.681959

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