Article

An Epigenetic Signature of Vulnerable Neurons is Under Selective Pressure Associated with Longevity Across Placental Mammals.

2026-08-25

Abstract excerpt

Age is the primary risk factor for neurodegenerative diseases, which are characterized by cell-type-specific vulnerability. Yet brain-aging mechanisms remain unclear given the complex, interacting age-associated pathways across diverse neural cell types. Here, we dissect cell type- cell state-specific aging gene regulatory programs and their contribution to cellular vulnerability by leveraging epigenomics, AI meth...

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Literature Corpus work: 732dcd8d-6d99-5498-88d1-21fc797d7b0b
DOI: 10.64898/2026.08.20.745782

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