Article

Apremilast reverses the profibrotic phenotype of dermal fibroblasts derived from patients with systemic sclerosis and prevents the progression of bleomycin-induced dermal fibrosis in mice

2023-03-02

Abstract excerpt

Phosphodiesterase (PDE) 4 inhibitors have been reported to suppress the progression of dermal fibrosis in patients with systemic sclerosis (SSc); however, the precise mechanisms remain to be elucidated. Therefore, we conducted experiments focusing on the antifibrotic and anti-inflammatory effects of apremilast using dermal fibroblasts derived from patients with SSc and an SSc mouse model. Dermal fibroblasts derive...

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Literature Corpus work: 6d8abfd0-2785-57ec-8c7e-7e15e765bb86
DOI: 10.21203/rs.3.rs-2610128/v1

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