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Canonical Wnt signalling as a key regulator of fibrogenesis – implications for targeted therapies?

12 Oct 2013

Abstract excerpt

Canonical Wnt signalling belongs to the so-called morphogen pathways and plays essential roles in development and tissue homeostasis. Being such a crucial regulatory pathway, Wnt signalling is tightly controlled at different levels. However, uncontrolled activation of canonical Wnt signalling has been implicated into the pathogenesis of various human disorders. In the last years, aberrant Wnt signalling has been...

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PMID: 24118232
DOI: 10.1111/exd.12255

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