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Article

Astragaloside IV alleviates skin fibrosis by modulating fibroblast phenotype in keloids.

European journal of dermatology : EJD - 1 Oct 2024

Gao Hu, Sun Xian, Zhang Xiangming

Abstract excerpt

Keloids are fibroproliferative diseases featuring abnormal fibroblast proliferation and extracellular matrix (ECM) deposition. Current therapeutic methods for keloids are unsatisfactory, and the recurrence rates of keloids are high. Astragaloside IV (AS-IV) is a key active component of Astragalus membranaceus Bunge, and has been reported to exert potent anti-fibrotic effects. Accordingly, our research aimed to...

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Identifiers

PMID: 39589029
DOI: 10.1684/ejd.2024.4754

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