Article

RUNX1 is Expressed in a Subpopulation of Dermal Fibroblasts and Higher RUNX1 Levels are Associated with the Severity of Systemic Sclerosis

2024-04-05

Abstract excerpt

The activation of Runt-related transcription factor 1 (RUNX1) in fibroblasts has been implicated in wound healing and fibrosis; however, the role of RUNX1 in the fibrotic progression of the autoimmune disease systemic sclerosis (SSc) is not known. Through gene expression analysis, we have demonstrated an association between the severity of dermal fibrosis and the expression levels of RUNX1 in the skin of patients...

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Literature Corpus work: a29bbbf7-0433-51e5-812c-45ad2cc56af1
DOI: 10.1101/2024.04.03.587966

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