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Article

Endoglin promotes TGF-β/Smad1 signaling in scleroderma fibroblasts.

Journal of cellular physiology - 1 Dec 2011

Morris Erin, Chrobak Izabela, Bujor Andreea, Hant Faye, Mummery Christine, Ten Dijke Peter, Trojanowska Maria

Abstract excerpt

TGF-β is the primary inducer of extracellular matrix proteins in scleroderma (systemic sclerosis, SSc). Previous studies indicate that in a subset of SSc fibroblasts TGF-β signaling is activated via elevated levels of activin receptor-like kinase (ALK) 1 and phosphorylated Smad1 (pSmad1). The goa...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21344387
DOI: 10.1002/jcp.22690
PMCID: PMC3381731

Genes

CCN2
ALK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21344387-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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