Article

The Compound LG283 Inhibits Bleomycin-induced Skin Fibrosis and Vascular Injury via Antagonizing TGF-β /Smad/Snail Mesenchymal Transition Pathways

2021-05-29

Abstract excerpt

<title>Abstract</title> <p>BackgroundSystemic sclerosis (SSc) is a collagen disease that exhibits intractable fibrosis and vascular injury of the skin and internal organs. Transforming growth factor-β (TGF-β)/Smad signaling plays a central role in extracellular matrix (ECM) production by myofibroblasts. Myofibroblasts may be derived from epithelial and endothelial precursor cells in addition to resident fibroblas...

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Literature Corpus work: 3c55b049-c98e-521c-8b7d-96054323bac1
DOI: 10.21203/rs.3.rs-529685/v1

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