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Article

Attenuation of fibrosis in vitro and in vivo with SPARC siRNA

1 Apr 2010

Abstract excerpt

INTRODUCTION: SPARC is a matricellular protein, which, along with other extracellular matrix components including collagens, is commonly over-expressed in fibrotic diseases. The purpose of this study was to examine whether inhibition of SPARC can regulate collagen expression in vitro and in vivo, and subsequently attenuate fibrotic stimulation by bleomycin in mouse skin and lungs. METHODS: In in vitro studies,...

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PMID: 20359365
DOI: 10.1186/ar2973

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