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Article

Tamibarotene Ameliorates Bleomycin-Induced Dermal Fibrosis by Modulating Phenotypes of Fibroblasts, Endothelial Cells, and Immune Cells.

The Journal of investigative dermatology - 1 Feb 2016

Toyama Tetsuo, Asano Yoshihide, Akamata Kaname, Noda Shinji, Taniguchi Takashi, Takahashi Takehiro, Ichimura Yohei, Shudo Koichi, Sato Shinichi, Kadono Takafumi

Abstract excerpt

Tamibarotene (Am80) is a synthetic retinoid that modulates the pathologic processes of various autoimmune and inflammatory diseases and their animal models. We here investigated the therapeutic potential of Am80 against systemic sclerosis using its animal models. Am80 significantly attenuated dermal and hypodermal fibrosis in bleomycin (BLM)-treated mice and tight skin 1 mice, respectively. Consistently, Am80...

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Identifiers

PMID: 26967475
DOI: 10.1016/j.jid.2015.10.058

Genes

BLM

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