Article

The differential effects of cAMP mobilizing agents on TGF-β-induced extracellular matrix in human lung-derived fibroblasts: Insights into therapeutic targets for lung fibrosis

2025-08-22

Abstract excerpt

<title>Abstract</title> <p> <bold>Background:</bold> Injury-repair responses typically induce tissue or organ scarring. Generally, cAMP-mobilizing agents inhibit the activation of fibroblasts and deposition of extracellular matrix. Some but not all cAMP-mobilizing agents inhibit fibrosis. Evidence suggests that inhaled treprostinil, a prostacyclin (IP) analog, increases intracellular cAMP levels [cAMP] <sub>I<...

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Literature Corpus work: bc138d06-9b81-5899-872b-67fd910449aa
DOI: 10.21203/rs.3.rs-7321140/v1

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