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Article

Transforming growth factor-beta in systemic sclerosis scleroderma

1 Jan 2009

Abstract excerpt

Deregulated transforming growth factor-beta (TGF-beta) activity and responses play prominent roles in the pathogenesis of systemic sclerosis (SSc), a chronic and progressive connective tissue disease characterized by fibrosis of the skin and internal organs. Systemic sclerosis has highly heterogeneous clinical manifestations, and patients can be classified into multiple subgroups on the basis of distinct...

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PMID: 19482698
DOI: 10.2741/s22

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