Article

Distinct cAMP regulation in scleroderma lung and skin myofibroblasts governs their dedifferentiation via p38α inhibition

2025-03-01

Abstract excerpt

<h4>ABSTRACT</h4> Fibrosis in systemic sclerosis/scleroderma (SSc) is characterized by the progressive accumulation and persistence in multiple organs of pathologic fibroblasts whose contractile properties and exuberant secretion of collagens promote tissue stiffness and scarring. Identifying a tractable mechanism for inactivating and possibly clearing these ultimate effector cells of fibrosis, conventionally ter...

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Literature Corpus work: 8bcf398b-e690-5dc1-85f8-4f48de093517
DOI: 10.1101/2025.02.26.640163

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