Loss of Y chromosome in Alzheimer's patients co-occurs with somatic mutations beyond CHIP drivers.

doi:10.26508/lsa.202503533

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Loss of Y chromosome in Alzheimer's patients co-occurs with somatic mutations beyond CHIP drivers.

Life science alliance - 1 Feb 2026

Rychlicka-Buniowska Edyta, Sarkisyan Daniil, Horbacz Monika, Bruhn-Olszewska Bożena, Drężek-Chyła Kinga, Koszyński Mikołaj, Davies Hanna, Juhas Ulana, Wójcik-Zalewska Magdalena, Klich-Rączka Alicja, Kilander Lena, Ingelsson Martin, Bukowska-Strakova Karolina, Węglarczyk Kazimierz, Siedlar Maciej, Baran Jarosław, Ryś Janusz, Piotrowski Arkadiusz, Filipowicz Natalia, Dumanski Jan P

Abstract excerpt

Loss of Y chromosome (LOY) and clonal hematopoiesis of indeterminate potential (CHIP) are common age-related events with implications for aging and Alzheimer disease (AD). LOY is linked to increased AD risk, whereas CHIP may be protective, and their co-occurrence remains unclear. We conducted whole-exome sequencing of CD4+ T cells, NK cells, and myeloid cells from AD patients and controls exhibiting LOY or...

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PMID: 41371958
DOI: 10.26508/lsa.202503533
PMCID: PMC12696397

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