Article

Loss of Y chromosome in Alzheimer disease patients co-occurs with clonal hematopoiesis defined by post-zygotic point mutations outside canonical CHIP driver genes

2025-06-06

Abstract excerpt

Loss of Y chromosome (LOY) and clonal hematopoiesis of indeterminate potential (CHIP) are common age-related events associated with multiple adverse outcomes in the elderly. While LOY has been associated with higher risk of Alzheimer disease (AD), CHIP has been suggested to perform a protective role against AD. Moreover, the co-occurrence of CHIP and LOY is debated. We performed deep whole-exome sequencing of FACS...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 042a17c5-376d-50a4-8f16-2f121731663f
DOI: 10.1101/2025.06.05.25329040

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Loss of Y chromosome in Alzheimer disease patients co-occurs with clonal hematopoiesis defined by post-zygotic point mutations outside canonical CHIP driver genesDOI 10.1101/2025.06.05.25329040Read

Loss of Y chromosome in Alzheimer's patients co-occurs with somatic mutations beyond CHIP drivers.Semantic proximity Read

Clonal Hematopoiesis Mutations Increase Risk of Alzheimer’s Disease with <i>APOE</i> ε3/ε3 GenotypeSemantic proximity Read

Loss of Y and clonal hematopoiesis in blood—two sides of the same coin?Semantic proximity Read

Mosaic loss of chromosome Y in aged human microgliaSemantic proximity Read

Clonal hematopoiesis is associated with protection from Alzheimer’s diseaseSemantic proximity Read

Genomic and phenomic landscape of clonal hematopoiesis in over a million ancestrally diverse participantsSemantic proximity Read

Mosaic chromosomal alterations in blood are associated with an increased risk of Alzheimer’s diseaseSemantic proximity Read

Mosaic Loss of Chromosome Y in Blood Is Associated with Alzheimer Disease.Semantic proximity Read

Loss of Y is associated with multi-omic changes in immune cells from Alzheimer’s disease patientsSemantic proximity Read

Clonal hematopoiesis is associated with protection from Alzheimer's disease.Semantic proximity Read

Association Between Clonal Hematopoiesis of Indeterminate Potential and Brain β-Amyloid Deposition in Korean Patients With Cognitive Impairment.Semantic proximity Read

The genomic landscape of clonal hematopoiesis in JapanSemantic proximity Read