Article

Loss of Y is associated with multi-omic changes in immune cells from Alzheimer’s disease patients

2023-02-08

Abstract excerpt

<h4>ABSTRACT</h4> Alzheimer’s disease (AD) is a common and increasing societal problem due to the extending human lifespan. In males, loss of Y (LOY) in leukocytes is more prevalent in AD patients. We studied DNA methylation, gene expression and other epigenetic changes in monocytes and granulocytes with and without LOY from male AD patients and controls. New candidate genes were identified and numerous genes alre...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fc983d1f-895a-50a8-82c4-2ffcfb3f92ba
DOI: 10.1101/2023.02.07.23285520

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Loss of Y is associated with multi-omic changes in immune cells from Alzheimer’s disease patientsDOI 10.1101/2023.02.07.23285520Read

DNA methylation patterns contribute to changes of cellular differentiation pathways in leukocytes with LOY from patients with Alzheimer’s diseaseSemantic proximity Read

Single-cell multi-omic profiling allows the dissection of peripheral immune phenotypes in Alzheimer’s Disease progressionSemantic proximity Read

Common DNA methylation alterations of Alzheimer's disease and aging in peripheral whole blood.Semantic proximity Read

Loss of Y chromosome in Alzheimer's patients co-occurs with somatic mutations beyond CHIP drivers.Semantic proximity Read

Genomic partitioning of Alzheimer’s disease in humans reveals non-CNS etiologySemantic proximity Read

Mosaic loss of chromosome Y in aged human microgliaSemantic proximity Read

Identification of molecular alterations in leukocytes from gene expression profiles of peripheral whole blood of Alzheimer’s diseaseSemantic proximity Read

Advances in Genetics and Epigenetic Alterations in Alzheimer's Disease: A Notion for Therapeutic Treatment.Semantic proximity Read

Mosaic Loss of Chromosome Y in Blood Is Associated with Alzheimer Disease.Semantic proximity Read

Epigenetic aging of classical monocytes from healthy individualsSemantic proximity Read

Tracking the progression of Alzheimer’s disease with peripheral blood monocytesSemantic proximity Read

Integrated DNA methylation and gene expression profiling across multiple brain regions implicate novel genes in Alzheimer’s diseaseSemantic proximity Read