Article

Single-cell mosaicism analysis reveals cell-type-specific somatic mutational burden in Alzheimer’s Dementia

2022-04-22

Abstract excerpt

Despite significant advances in identifying genetic drivers of neurodegenerative disorders, the majority of affected individuals lack molecular genetic diagnosis, with somatic mutations proposed as one potential contributor to increased risk. Here, we report the first cell-type-specific map of somatic mosaicism in Alzheimer’s Dementia (AlzD), using 4,014 cells from prefrontal cortex samples of 19 AlzD and 17 non-A...

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Literature Corpus work: 4517aaa5-3167-5b16-a406-add51c31c166
DOI: 10.1101/2022.04.21.489103

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