Article

A single-nuclei RNA sequencing study of Mendelian and sporadic AD in the human brain

2019-03-30

Abstract excerpt

Alzheimer Disease (AD) is the most common form of dementia. This neurodegenerative disorder is associated with neuronal death and gliosis heavily impacting the cerebral cortex. AD has a substantial but heterogeneous genetic component, presenting both Mendelian and complex genetic architectures. Using bulk RNA-seq from parietal lobes and deconvolution methods, we previously reported that brains exhibiting different...

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Literature Corpus work: e1d7428b-e35f-5d4f-ba10-251acb00b912
DOI: 10.1101/593756

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