Article

Immune cells lacking Y chromosome have widespread dysregulation of autosomal genes

2019-06-18

Abstract excerpt

Mosaic loss of chromosome Y (LOY) in leukocytes has been associated with many diseases, yet it remains unclear whether this form of clonal mosaicism exerts a direct physiological effect. Here we perform single-cell and bulk RNA sequencing in leukocytes, observing considerable variation in the rate of LOY across individuals, cell types and disease state. Cells with LOY demonstrated a profound degree of transcriptio...

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Literature Corpus work: 77a8373d-5437-5d76-87c8-34e81527ed5f
DOI: 10.1101/673459

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