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Article

[Ethical and clinical aspects of genetic analysis in neurodegenerative diseases].

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova - 1 Jan 2026

Yusupov F A, Abdykadyrov M Sh

Abstract excerpt

OBJECTIVE: Too conduct a comprehensive analytical review of the limitations of traditional genetic methodologies compared with contemporary high-resolution technologies, such as single-cell and single-nucleus RNA sequencing (sc/snRNA-seq). It will explore in detail the mechanisms underlying the incomplete penetrance of pivotal risk genes, namely LRRK2 and GBA1, and systematically organize data on pathological...

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Identifiers

PMID: 42565395
DOI: 10.17116/jnevro202612607115

Genes

GBA1

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