Article

Mosaic chromosomal alterations in blood are associated with an increased risk of Alzheimer’s disease

2025-06-04

Abstract excerpt

Mosaic chromosomal alterations (mCAs) in blood, a form of clonal hematopoiesis, have been linked to various diseases, but their role in Alzheimer’s disease (AD) remains unclear. We analyzed blood whole-genome sequencing (WGS) data from 24,049 individuals in the Alzheimer’s Disease Sequencing Project and found that autosomal mCAs were significantly associated with increased AD risk (odds ratio = 1.27; P = 1.3 × 10...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 02762edd-386a-5ad1-abee-1187006bd044
DOI: 10.1101/2025.05.29.25328544

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Mosaic chromosomal alterations in blood are associated with an increased risk of Alzheimer’s diseaseDOI 10.1101/2025.05.29.25328544Read

Clonal hematopoiesis is associated with protection from Alzheimer’s diseaseSemantic proximity Read

Clonal hematopoiesis is associated with protection from Alzheimer's disease.Semantic proximity Read

Mosaic loss of chromosome Y in aged human microgliaSemantic proximity Read

Loss of Y chromosome in Alzheimer's patients co-occurs with somatic mutations beyond CHIP drivers.Semantic proximity Read

A public resource of single cell transcriptomes and multiscale networks from persons with and without Alzheimer’s diseaseSemantic proximity Read

Clonal Hematopoiesis Mutations Increase Risk of Alzheimer’s Disease with <i>APOE</i> ε3/ε3 GenotypeSemantic proximity Read

Genomic partitioning of Alzheimer’s disease in humans reveals non-CNS etiologySemantic proximity Read

Loss of Y chromosome in Alzheimer disease patients co-occurs with clonal hematopoiesis defined by post-zygotic point mutations outside canonical CHIP driver genesSemantic proximity Read

Somatic cancer driver mutations are enriched and associated with inflammatory states in Alzheimer’s disease microgliaSemantic proximity Read

A single-nuclei RNA sequencing study of Mendelian and sporadic AD in the human brainSemantic proximity Read

Cell type-specific associations with Alzheimer’s Disease conserved across racial and ethnic groupsSemantic proximity Read

Loss of Y is associated with multi-omic changes in immune cells from Alzheimer’s disease patientsSemantic proximity Read