Article

Common variants associated with <i>OSMR</i> expression contribute to carotid plaque vulnerability, but not to cardiovascular disease in humans

2019-03-14

Abstract excerpt

<h4>Background and aims</h4> Oncostatin M (OSM) signaling is implicated in atherosclerosis, however the mechanism remains unclear. We investigated the impact of common genetic variants in OSM and its receptors, OSMR and LIFR , on overall plaque vulnerability, plaque phenotype, intraplaque OSMR and LIFR expression, coronary artery calcification burden and cardiovascular disease susceptibility. <h4>Methods and...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6d39cabc-44d2-563e-9d08-ee8965efd6a7
DOI: 10.1101/576793

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Common variants associated with <i>OSMR</i> expression contribute to carotid plaque vulnerability, but not to cardiovascular disease in humansDOI 10.1101/576793Read

A multi-omics approach uncovers causality of IL6R on endotypes of subclinical carotid atherosclerosis and the possible role of the IL6R/OSMR pathway.Semantic proximity Read

The 9p21.3 Coronary Artery Disease Risk Locus Drives Vascular Smooth Muscle Cells to an Osteochondrogenic State.Semantic proximity Read

Atherosclerotic fibrous plaques in females are characterized by endothelial-to-mesenchymal transition and linked to smokingSemantic proximity Read

Variants in ALOX5, ALOX5AP and LTA4H are not associated with atherosclerotic plaque phenotypes: the Athero-Express Genomics Study.Semantic proximity Read

Loss of Y Chromosome in Blood Is Associated With Major Cardiovascular Events During Follow-Up in Men After Carotid Endarterectomy.Semantic proximity Read

Genetic and atherosclerotic plaque immunohistochemical analyses do not associate reduced sclerostin expression with cardiovascular eventsSemantic proximity Read

Hypoxia-induced endothelial exosomal MSTRG.12883.2 enhances ox-LDL- induced phenotypic switching of vascular smooth muscle cells.Semantic proximity Read

LMO7 regulates smooth muscle cell cholesterol esterification to influence plaque stabilitySemantic proximity Read

Impact of Y loss in blood on male atherosclerosis and cardiovascular riskSemantic proximity Read

Sclerostin Downregulation Globally by Naturally Occurring Genetic Variants, or Locally in Atherosclerotic Plaques, Does Not Associate With Cardiovascular Events in HumansSemantic proximity Read

Reduced STK11 Expression Is Associated with Vulnerable Phenotypes in Human Carotid Atherosclerotic PlaquesSemantic proximity Read

Role of six single nucleotide polymorphisms, risk factors in coronary disease, in OLR1 alternative splicing.Semantic proximity Read