Article

Impact of Y loss in blood on male atherosclerosis and cardiovascular risk

2026-03-12

Abstract excerpt

<title>Abstract</title> <p>Atherosclerotic cardiovascular disease shows a marked male predominance(1–3), yet the biological basis for this disparity remains unclear. Mosaic loss of chromosome Y (LOY) in blood – a common, acquired and age associated mutation(4,5)- has been linked to mortality and major causes of death, including myocardial infarction(6,7). Experimental studies indicate that LOY in leukocytes is ca...

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Literature Corpus work: 27531a74-1dbe-5fa4-9dce-a095a80128fd
DOI: 10.21203/rs.3.rs-8902444/v1

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