A multi-omics approach uncovers causality of IL6R on endotypes of subclinical carotid atherosclerosis and the possible role of the IL6R/OSMR pathway.

doi:10.1093/cvr/cvaf177

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Article

A multi-omics approach uncovers causality of IL6R on endotypes of subclinical carotid atherosclerosis and the possible role of the IL6R/OSMR pathway.

Cardiovascular research - 9 Dec 2025

Chen Qiao Sen, Björck Hanna M, Bergman Otto, Baldassarre Damiano, Engström Gunnar, Gallo Antonio, Gummesson Anders, Hedin Ulf, Kurl Sudhir, Lind Lars, Matic Ljubica, Mulder Douw Johannes, Pirro Matteo, Savonen Kai, Söderberg Stefan, Veglia Fabrizio, Tremoli Elena, Östgren Carl Johan, Eriksson Per, Strawbridge Rona J, Gigante Bruna

Abstract excerpt

AIMS: Endotypes integrate individual clinical and molecular data and can be used to formulate molecular subclassifications of diseases. We previously derived four endotypes of subclinical carotid atherosclerosis in a large European cohort, c-IMT and c-IMT Progression as Predictors of Vascular Events in a High-Risk European Population (IMPROVE), identifying individuals with a specific cardiovascular (CV) risk,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41124095
DOI: 10.1093/cvr/cvaf177
PMCID: PMC12687871

Genes

IL6R
OSMR
CFB
FGA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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