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Article

Hypoxia-induced endothelial exosomal MSTRG.12883.2 enhances ox-LDL- induced phenotypic switching of vascular smooth muscle cells.

Life sciences - 1 Aug 2026

Yin Renqi, Zhang Guoxin, Ruan Peng, Qu Lefeng, Shen Zhenwei, Zhi Kangkang

Abstract excerpt

AIMS: Plaque regions in atherosclerosis (AS) exhibit sustained moderate hypoxia, which may impair endothelial function and influence vascular smooth muscle cell (VSMC) behavior. This study aims to investigate hypoxia-responsive endothelial-derived long noncoding RNAs (lncRNAs), and their role in enhancing oxidized low-density lipoprotein(ox-LDL)-induced phenotypic switching of VSMCs. MATERIALS AND METHODS:...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42107690
DOI: 10.1016/j.lfs.2026.124450

Genes

KLF4
CCK

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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