Article
Variants in ALOX5, ALOX5AP and LTA4H are not associated with atherosclerotic plaque phenotypes: the Athero-Express Genomics Study.
Atherosclerosis - 1 Apr 2015
van der Laan Sander W, Foroughi Asl Hassan, van den Borne Pleunie, van Setten Jessica, van der Perk M E Madeleine, van de Weg Sander M, Schoneveld Arjan H, de Kleijn Dominique P V, Michoel Tom, Björkegren Johan L M, den Ruijter Hester M, Asselbergs Folkert W, de Bakker Paul I W, Pasterkamp Gerard
Abstract excerpt
BACKGROUND: The eicosanoid genes ALOX5, ALOX5AP and LTA4H have been implicated in atherosclerosis. We assessed the impact of common variants in these genes on gene expression, circulating protein levels, and atherosclerotic plaque phenotypes. METHODS: We included patients from the Stockholm Atherosclerosis Gene Expression study (STAGE, N = 109), and the Athero-Express Biobank Study (AE, N = 1443). We tested 1453...
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