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Article

Role of six single nucleotide polymorphisms, risk factors in coronary disease, in OLR1 alternative splicing.

RNA (New York, N.Y.) - 1 Jun 2015

Tejedor J Ramón, Tilgner Hagen, Iannone Camilla, Guigó Roderic, Valcárcel Juan

Abstract excerpt

The OLR1 gene encodes the oxidized low-density lipoprotein receptor (LOX-1), which is responsible for the cellular uptake of oxidized LDL (Ox-LDL), foam cell formation in atheroma plaques and atherosclerotic plaque rupture. Alternative splicing (AS) of OLR1 exon 5 generates two protein isoforms with antagonistic functions in Ox-LDL uptake. Previous work identified six single nucleotide polymorphisms (SNPs) in...

Topics

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Alternative Splicing
Coronary Disease
Lipoproteins, LDL
Regulatory Sequences, Ribonucleic Acid
Ribonucleoproteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA-Binding Proteins

Scavenger Receptors, Class E

Serine-Arginine Splicing Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 25904137
DOI: 10.1261/rna.049890.115
PMCID: PMC4436670

Genes

OLR1
HMGA1
SRSF1
SRSF2
LOX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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