Article

Genetic and atherosclerotic plaque immunohistochemical analyses do not associate reduced sclerostin expression with cardiovascular events

2020-11-23

Abstract excerpt

The sclerostin antibody romosozumab increases bone formation and decreases bone resorption, leading to increased bone mass, bone mineral density and bone strength, and reduced fracture risk. In a clinical study versus alendronate in postmenopausal women (ARCH), an imbalance in adjudicated serious cardiovascular (CV) events driven by an increase in myocardial infarction (MI) and stroke was observed. To investigate...

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Literature Corpus work: 4a01c7c9-708e-5715-8b12-2af4b95b423b
DOI: 10.1101/2020.11.20.20235234

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