Article
Loss of Y Chromosome in Blood Is Associated With Major Cardiovascular Events During Follow-Up in Men After Carotid Endarterectomy.
Circulation. Cardiovascular genetics - 1 Aug 2017
Haitjema Saskia, Kofink Daniel, van Setten Jessica, van der Laan Sander W, Schoneveld Arjan H, Eales James, Tomaszewski Maciej, de Jager Saskia C A, Pasterkamp Gerard, Asselbergs Folkert W, den Ruijter Hester M
Abstract excerpt
BACKGROUND: Recent studies found an immune regulatory role for Y chromosome and a relationship between loss of Y chromosome (LOY) in blood cells and a higher risk of cancer and mortality. Given involvement of immune cells in atherosclerosis, we hypothesized that LOY is associated with the severity of atherosclerotic plaque characteristics and outcome in men undergoing carotid endarterectomy. METHODS AND RESULTS:...
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