Article

Contrasting Effects of Platelet GPVI Deletion versus Syk Inhibition on Mouse Jugular Vein Puncture Wound Structure

2025-01-31

Abstract excerpt

Platelet glycoprotein (GP)VI is a transmembrane protein that was originally characterized as a collagen receptor supporting platelet adhesion and activation through its association with the Fc receptor g-chain (FcRg). The FcRg subunit contains immunoreceptor tyrosine-based activation motifs (ITAMs) that recruit and activate Syk (spleen tyrosine kinase), a key player in intracellular signaling pathways. Absence or...

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Literature Corpus work: 6ceb6f26-fb96-57f4-814e-a5e4f9ef9b17
DOI: 10.20944/preprints202501.2330.v1

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