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Article

Proplatelet formation is selectively inhibited by collagen type I through Syk-independent GPVI signaling.

Journal of cell science - 15 Sept 2016

Semeniak Daniela, Kulawig Rebecca, Stegner David, Meyer Imke, Schwiebert Silke, Bösing Hendrik, Eckes Beate, Nieswandt Bernhard, Schulze Harald

Abstract excerpt

Collagen receptors GPVI (also known as GP6) and integrin α2β1 are highly expressed on blood platelets and megakaryocytes, their immediate precursors. After vessel injury, subendothelial collagen becomes exposed and induces platelet activation to prevent blood loss. Collagen types I and IV are thought to have opposite effects on platelet biogenesis, directing proplatelet formation (PPF) towards the blood vessels...

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PMID: 27505889
DOI: 10.1242/jcs.187971

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