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Article

Functional phenotype of phosphoinositide 3-kinase p85alpha-null platelets characterized by an impaired response to GP VI stimulation.

Blood - 15 Jul 2003

Watanabe Naohide, Nakajima Hideaki, Suzuki Hidenori, Oda Atsushi, Matsubara Yumiko, Moroi Masaaki, Terauchi Yasuo, Kadowaki Takashi, Suzuki Harumi, Koyasu Shigeo, Ikeda Yasuo, Handa Makoto

Abstract excerpt

Phosphoinositide 3-kinases (PI3Ks), a family of lipid kinases comprising 3 classes with multiple isoforms, have been shown to participate in different phases of platelet signaling. To investigate the roles that enzymes play in platelet function in vivo and determine which isoforms are important for particular signaling events, we analyzed platelet function of gene knockout mice deficient in the p85alpha...

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PMID: 12649157
DOI: 10.1182/blood-2002-11-3327

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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