Article

The secreted tyrosine kinase VLK is essential for normal platelet activation and thrombus formation

2021-01-26

Abstract excerpt

Tyrosine phosphorylation of extracellular proteins is observed in cell cultures and in vivo, but little is known about the functional roles of tyrosine phosphorylation of extracellular proteins. Vertebrate Lonesome Kinase (VLK) is a broadly expressed secretory pathway tyrosine kinase present in platelet ɑ-granules. It is released from platelets upon activation and phosphorylates substrates extracellularly. Its rol...

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Literature Corpus work: 6834d69e-3aa6-5b1b-89d8-f379d1cc55d0
DOI: 10.1101/2021.01.24.427281

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